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DUSP15 dual specificity phosphatase 15 [ Homo sapiens (human) ]

Gene ID: 128853, updated on 5-Mar-2024

Summary

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Official Symbol
DUSP15provided by HGNC
Official Full Name
dual specificity phosphatase 15provided by HGNC
Primary source
HGNC:HGNC:16236
See related
Ensembl:ENSG00000149599 MIM:616776; AllianceGenome:HGNC:16236
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VHY; C20orf57
Summary
The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Biased expression in testis (RPKM 10.5), kidney (RPKM 3.2) and 1 other tissue See more
Orthologs
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Genomic context

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Location:
20q11.21
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (31845593..31870664, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33570201..33595274, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30435440..30458467, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17699 Neighboring gene TPX2 microtubule nucleation factor Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30373423-30373922 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30376059-30376558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30403487-30404289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30407643-30408184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30411041-30411568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30411569-30412095 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30412296-30412796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30414489-30414989 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30421849-30422479 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30424845-30425692 Neighboring gene myosin light chain kinase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30432791-30433348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12766 Neighboring gene forkhead box S1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30467121-30467620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12770 Neighboring gene tubulin tyrosine ligase like 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17702 Neighboring gene Sharpr-MPRA regulatory region 918 Neighboring gene RNA, U1 small nuclear 94, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17704 Neighboring gene p53 and DNA damage regulated 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein. Bhore N, et al. Mol Neurobiol, 2021 May. PMID 33417224
  2. Association of oligodendrocytes differentiation regulator gene DUSP15 with autism. Tian Y, et al. World J Biol Psychiatry, 2017 Mar. PMID 27223645
  3. Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase. Yoon TS, et al. Proteins, 2005 Nov 15. PMID 16170801
  4. Association between Genetic Variants in DUSP15, CNTNAP2, and PCDHA Genes and Risk of Childhood Autism Spectrum Disorder. Fang F, et al. Behav Neurol, 2021. PMID 34257739, Free PMC Article
  5. Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach. Schmidt F, et al. PLoS One, 2012. PMID 22792334, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein.
    Title: Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein.
  2. Association between Genetic Variants in DUSP15, CNTNAP2, and PCDHA Genes and Risk of Childhood Autism Spectrum Disorder.
    Title: Association between Genetic Variants in DUSP15, CNTNAP2, and PCDHA Genes and Risk of Childhood Autism Spectrum Disorder.
  3. The results showed that dual specificity phosphatase 15 (DUSP15) rs3746599 was significantly associated with autism under allelic, additive and dominant models,The findings initially suggest that DUSP15 might be a susceptibility gene for autism in Chinese Han population.
    Title: Association of oligodendrocytes differentiation regulator gene DUSP15 with autism.
  4. Dusp15/VHY is a key regulator of oligodendrocyte differentiation, and PDGFR-beta and SNX6 are novel and specific Dusp15 substrates.
    Title: Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach.
  5. VHY is a new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases
    Title: VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.
  6. crystal structure of catalytic domain
    Title: Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20645, FLJ40111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 15
Names
VH1-related member Y
dual specificity phosphatase-like 15
vaccinia virus VH1-related dual-specific protein phosphatase Y
NP_001012662.1
NP_001307407.1
NP_001307408.1
NP_542178.2
NP_817130.1
XP_016883143.1
XP_016883144.1
XP_016883145.1
XP_016883146.1
XP_016883147.1
XP_016883148.1
XP_016883149.1
XP_016883150.1
XP_016883151.1
XP_047295846.1
XP_047295847.1
XP_054178944.1
XP_054178945.1
XP_054178946.1
XP_054178947.1
XP_054178948.1
XP_054178949.1
XP_054178950.1
XP_054178951.1
XP_054178952.1
XP_054178953.1
XP_054178954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012644.3 → NP_001012662.1  dual specificity protein phosphatase 15 isoform b

    See identical proteins and their annotated locations for NP_001012662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to isoform a. Variants 2 and 3 both encode isoform b, which has a shorter N-terminus than isoform a.
    Source sequence(s)
    AI051640, AK091960, AL732169, BC056911, BF377396, DN996690
    Consensus CDS
    CCDS42862.1
    UniProtKB/Swiss-Prot
    Q9H1R2
    Related
    ENSP00000381157.1, ENST00000398083.5
    Conserved Domains (1) summary
    cl21483
    Location:1 → 35
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_001320478.1 → NP_001307407.1  dual specificity protein phosphatase 15 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (c) has a distinct, shorter N-terminus than isoform a.
    Source sequence(s)
    AI051640, AK091960, AK097430, BM554314
    Consensus CDS
    CCDS82607.1
    UniProtKB/Swiss-Prot
    Q9H1R2
    Related
    ENSP00000365133.4, ENST00000375966.8
    Conserved Domains (1) summary
    cd00127
    Location:1 → 135
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  3. NM_001320479.1 → NP_001307408.1  dual specificity protein phosphatase 15 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains multiple differences at both the 5' and 3' ends, compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (d) has distinct N- and C-termini and is longer than isoform a.
    Source sequence(s)
    AK000652, AK097430
    Consensus CDS
    CCDS82606.1
    UniProtKB/Swiss-Prot
    A6NH79, A8MVC8, Q5QP62, Q5QP63, Q5QP65, Q6PGN7, Q8N826, Q9BX24, Q9H1R2
    Related
    ENSP00000278979.3, ENST00000278979.7
    Conserved Domains (1) summary
    cl28904
    Location:5 → 142
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. NM_080611.5 → NP_542178.2  dual specificity protein phosphatase 15 isoform a

    See identical proteins and their annotated locations for NP_542178.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AL160175
    Consensus CDS
    CCDS13193.1
    UniProtKB/Swiss-Prot
    Q9H1R2
    Related
    ENSP00000341658.5, ENST00000339738.10
    Conserved Domains (1) summary
    cd00127
    Location:4 → 138
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  5. NM_177991.3 → NP_817130.1  dual specificity protein phosphatase 15 isoform b

    See identical proteins and their annotated locations for NP_817130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to isoform a. Variants 2 and 3 both encode isoform b, which has a shorter N-terminus than isoform a.
    Source sequence(s)
    AI051640, AK091960, BI517878, DN996690
    Consensus CDS
    CCDS42862.1
    UniProtKB/Swiss-Prot
    Q9H1R2
    Related
    ENSP00000381158.2, ENST00000398084.6
    Conserved Domains (1) summary
    cl21483
    Location:1 → 35
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    31845593..31870664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027656.2 → XP_016883145.1  dual specificity protein phosphatase 15 isoform X3

  2. XM_017027655.2 → XP_016883144.1  dual specificity protein phosphatase 15 isoform X2

  3. XM_017027657.2 → XP_016883146.1  dual specificity protein phosphatase 15 isoform X4

  4. XM_017027654.2 → XP_016883143.1  dual specificity protein phosphatase 15 isoform X1

  5. XM_017027660.2 → XP_016883149.1  dual specificity protein phosphatase 15 isoform X5

  6. XM_017027658.2 → XP_016883147.1  dual specificity protein phosphatase 15 isoform X5

  7. XM_017027659.2 → XP_016883148.1  dual specificity protein phosphatase 15 isoform X5

  8. XM_017027662.2 → XP_016883151.1  dual specificity protein phosphatase 15 isoform X5

  9. XM_017027661.2 → XP_016883150.1  dual specificity protein phosphatase 15 isoform X5

  10. XM_047439890.1 → XP_047295846.1  dual specificity protein phosphatase 15 isoform X6

  11. XM_047439891.1 → XP_047295847.1  dual specificity protein phosphatase 15 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    33570201..33595274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322971.1 → XP_054178946.1  dual specificity protein phosphatase 15 isoform X3

  2. XM_054322970.1 → XP_054178945.1  dual specificity protein phosphatase 15 isoform X2

  3. XM_054322972.1 → XP_054178947.1  dual specificity protein phosphatase 15 isoform X4

  4. XM_054322969.1 → XP_054178944.1  dual specificity protein phosphatase 15 isoform X1

  5. XM_054322974.1 → XP_054178949.1  dual specificity protein phosphatase 15 isoform X5

  6. XM_054322973.1 → XP_054178948.1  dual specificity protein phosphatase 15 isoform X5

  7. XM_054322975.1 → XP_054178950.1  dual specificity protein phosphatase 15 isoform X5

  8. XM_054322977.1 → XP_054178952.1  dual specificity protein phosphatase 15 isoform X5

  9. XM_054322976.1 → XP_054178951.1  dual specificity protein phosphatase 15 isoform X5

  10. XM_054322978.1 → XP_054178953.1  dual specificity protein phosphatase 15 isoform X6

  11. XM_054322979.1 → XP_054178954.1  dual specificity protein phosphatase 15 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H1R2.4 GenPept UniProtKB/Swiss-Prot:Q9H1R2

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