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LOC128706665 uncharacterized LOC128706665 [ Homo sapiens (human) ]

Gene ID: 128706665, updated on 25-Mar-2024

Summary

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Gene symbol
LOC128706665
Gene description
uncharacterized LOC128706665
See related
Ensembl:ENSG00000285723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a short, well-conserved protein that is localized to the mitochondrial membrane. The encoded protein has been implicated in repression of translation of the downstream molecular chaperone MKKS protein. [provided by RefSeq, Mar 2023]
Orthologs
all
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Genomic context

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Location:
20p12.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (10413708..10434222, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (10456718..10477226, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17541 Neighboring gene ribosomal protein L23a pseudogene 6 Neighboring gene SDA1 domain containing 1 pseudogene 2 Neighboring gene uncharacterized LOC128706666 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:10399946-10401145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12671 Neighboring gene NANOG hESC enhancer GRCh37_chr20:10412265-10412766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17544 Neighboring gene MKKS centrosomal shuttling protein Neighboring gene SLX4 interacting protein Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:10447220-10447919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17545 Neighboring gene Sharpr-MPRA regulatory region 2397 Neighboring gene Sharpr-MPRA regulatory region 8388 Neighboring gene Sharpr-MPRA regulatory region 5326 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:10529678-10530178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17547 Neighboring gene Sharpr-MPRA regulatory region 6934 Neighboring gene Sharpr-MPRA regulatory region 11569 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:10578661-10579860 Neighboring gene DNAJC9 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:10617378-10618174 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:10618175-10618971 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:10621299-10622074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:10622075-10622850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12672 Neighboring gene microRNA 6870 Neighboring gene jagged canonical Notch ligand 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Translational repression of the McKusick-Kaufman syndrome transcript by unique upstream open reading frames encoding mitochondrial proteins with alternative polyadenylation sites. Akimoto C, et al. Biochim Biophys Acta, 2013 Mar. PMID 23671934
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Homology

General protein information

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Preferred Names
uncharacterized LOC128706665

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394148.2 → NP_001381077.1  uncharacterized LOC128706665

    Status: REVIEWED

    Source sequence(s)
    AL034430
    Consensus CDS
    CCDS93007.1
    UniProtKB/TrEMBL
    Q9HB66
    Related
    ENSP00000497510.1, ENST00000649912.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    10413708..10434222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    10456718..10477226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001417044.1: Suppressed sequence

    Description
    NM_001417044.1: This RefSeq was removed by NCBI staff.
Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases