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TSACC TSSK6 activating cochaperone [ Homo sapiens (human) ]

Gene ID: 128229, updated on 5-Mar-2024

Summary

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Official Symbol
TSACCprovided by HGNC
Official Full Name
TSSK6 activating cochaperoneprovided by HGNC
Primary source
HGNC:HGNC:30636
See related
Ensembl:ENSG00000163467 MIM:619679; AllianceGenome:HGNC:30636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIP; SSTK-IP; C1orf182
Summary
Enables chaperone binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 148.3) See more
Orthologs
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Genomic context

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Location:
1q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156337314..156346995)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155475925..155485606)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156307105..156316786)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156271210-156271710 Neighboring gene MPRA-validated peak424 silencer Neighboring gene glycosylated lysosomal membrane protein Neighboring gene VHL like Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156297025-156297871 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156297872-156298717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1859 Neighboring gene Rh family B glycoprotein Neighboring gene Sharpr-MPRA regulatory region 198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156362688-156363193 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156369951-156370626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156371301-156371974 Neighboring gene MIR9-1 host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156382372-156382872 Neighboring gene microRNA 9-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. Jha KN, et al. J Biol Chem, 2010 Nov 5. PMID 20829357, Free PMC Article
  2. Genome-wide association study of hematological and biochemical traits in a Japanese population. Kamatani Y, et al. Nat Genet, 2010 Mar. PMID 20139978
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC26877

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TSSK6-activating co-chaperone protein
Names
SSTK-interacting protein (SSTK-IP)
TSSK6 activating co-chaperone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304817.2 → NP_001291746.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_001291746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AK311950, BC014605, DB446801
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    D3DVB9, Q96A04
    Related
    ENSP00000357237.1, ENST00000368254.6
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  2. NM_001304818.2 → NP_001291747.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_001291747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AY048672, DB446801
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    D3DVB9, Q96A04
    Related
    ENSP00000357236.1, ENST00000368253.6
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  3. NM_001304819.2 → NP_001291748.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_001291748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AL589685, BC014605, HY019225, HY044099
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    D3DVB9, Q96A04
    Related
    ENSP00000357235.1, ENST00000368252.5
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  4. NM_001304820.1 → NP_001291749.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_001291749.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AI336861, BC014605
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    D3DVB9, Q96A04
    Related
    ENSP00000357234.1, ENST00000368251.1
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  5. NM_001304821.2 → NP_001291750.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_001291750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AL589685, BC014605, HY044099, HY230397
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    D3DVB9, Q96A04
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  6. NM_001304822.2 → NP_001291751.1  TSSK6-activating co-chaperone protein isoform b

    See identical proteins and their annotated locations for NP_001291751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
    Source sequence(s)
    BC014605, HY044771
    Consensus CDS
    CCDS76223.1
    UniProtKB/TrEMBL
    V9GYT6
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 57
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  7. NM_001304823.2 → NP_001291752.1  TSSK6-activating co-chaperone protein isoform b

    See identical proteins and their annotated locations for NP_001291752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
    Source sequence(s)
    BC014605, HY034095
    Consensus CDS
    CCDS76223.1
    UniProtKB/TrEMBL
    V9GYT6
    Related
    ENSP00000477074.1, ENST00000470342.5
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 57
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  8. NM_001304824.2 → NP_001291753.1  TSSK6-activating co-chaperone protein isoform b

    See identical proteins and their annotated locations for NP_001291753.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
    Source sequence(s)
    AL589685, BC014605, BE464129, HY044099
    Consensus CDS
    CCDS76223.1
    UniProtKB/TrEMBL
    V9GYT6
    Related
    ENSP00000477010.1, ENST00000466306.5
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 57
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  9. NM_001304825.2 → NP_001291754.1  TSSK6-activating co-chaperone protein isoform b

    See identical proteins and their annotated locations for NP_001291754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
    Source sequence(s)
    AL589685, BC014605, BI831108, HY044099
    Consensus CDS
    CCDS76223.1
    UniProtKB/TrEMBL
    V9GYT6
    Related
    ENSP00000476780.1, ENST00000481479.5
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 57
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  10. NM_001304826.2 → NP_001291755.1  TSSK6-activating co-chaperone protein isoform c

    See identical proteins and their annotated locations for NP_001291755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and uses two alternate splice junctions at the 5' end compared to variant 1. The resulting isoform (c) is longer at the N-terminus compared to isoform a.
    Source sequence(s)
    AL589685, AY048673, HY044099
    UniProtKB/Swiss-Prot
    Q96A04
    Conserved Domains (1) summary
    pfam15836
    Location:19 → 143
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

  11. NM_144627.5 → NP_653228.1  TSSK6-activating co-chaperone protein isoform a

    See identical proteins and their annotated locations for NP_653228.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
    Source sequence(s)
    AL589685, BC014605
    Consensus CDS
    CCDS1141.1
    UniProtKB/Swiss-Prot
    D3DVB9, Q96A04
    Related
    ENSP00000357238.3, ENST00000368255.7
    Conserved Domains (1) summary
    pfam15836
    Location:1 → 125
    SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

RNA

  1. NR_130913.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs at the 5' end, lacks an alternate internal exon, and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC014605, DB446801, HY048925

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156337314..156346995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155475925..155485606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96A04.1 GenPept UniProtKB/Swiss-Prot:Q96A04

Gene LinkOut

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