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mir-276a mir-276a stem loop [ Drosophila melanogaster (fruit fly) ]

Gene ID: 12798171, updated on 2-Nov-2024

Summary

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Official Symbol
mir-276aprovided by FlyBase
Official Full Name
mir-276a stem loopprovided by FlyBase
Primary source
FLYBASE:FBgn0266076
Locus tag
Dmel_CR43001
See related
miRBase:MI0000359; AllianceGenome:FB:FBgn0266076
Gene type
ncRNA
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
276a; CR33584; CR33585; CR43001; dme-mir-276; dme-mir-276a; dme-miR-276a; dme-miR-276a-3p; Dmel\CR43001; mir-276; miR-276; MIR-276; miR-276a; MiR-276a; miR-276a-3p; miR-276a-5p; mir-276aS; miR-276aS; rosa
Old locus tag
Dmel_CR33584; Dmel_CR33585
Summary
Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including learning or memory; miRNA-mediated post-transcriptional gene silencing; and negative regulation of insulin receptor signaling pathway. Predicted to be part of RISC complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mir-276a in Genome Data Viewer
Location:
67E2-67E2; 3-33 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10365228..10365325)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10358328..10358425)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46003 Neighboring gene long non-coding RNA:CR46449 Neighboring gene long non-coding RNA:CR46004 Neighboring gene long non-coding RNA:CR46006 Neighboring gene mir-276b stem loop Neighboring gene long non-coding RNA:CR45245 Neighboring gene long non-coding RNA:CR44543

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomewide clonal analysis of lethal mutations in the Drosophila melanogaster eye: comparison of the X chromosome and autosomes. Call GB, et al. Genetics, 2007 Oct. PMID 17720911, Free PMC Article
  2. Determinants of effective lentivirus-driven microRNA expression in vivo. Mishima T, et al. Sci Rep, 2016 Sep 15. PMID 27627961, Free PMC Article
  3. Ecdysone-induced microRNA miR-276a-3p controls developmental growth by targeting the insulin-like receptor in Drosophila. Lee S, et al. Insect Mol Biol, 2023 Dec. PMID 37702106
  4. Cardiac Timeless Trans-Organically Regulated by miR-276 in Adipose Tissue Modulates Cardiac Function. Tang C, et al. Function (Oxf), 2024. PMID 38058384, Free PMC Article
  5. mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression. Chen X, et al. Proc Natl Acad Sci U S A, 2016 May 24. PMID 27162360, Free PMC Article

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cardiac Timeless Trans-Organically Regulated by miR-276 in Adipose Tissue Modulates Cardiac Function.
    Title: Cardiac Timeless Trans-Organically Regulated by miR-276 in Adipose Tissue Modulates Cardiac Function.
  2. Regulatory mechanism of daily sleep by miR-276a.
    Title: Regulatory mechanism of daily sleep by miR-276a.
  3. mir-276a inhibits tim expression: Deleting the mir-276a-binding site in the tim 3' UTR causes elevated levels of TIM and approximately 50% arrhythmicity.
    Title: mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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  • alternate names: rosa; miR-276a; mir-276aS
  • mir-276a-RA; Dmel\mir-276a-RA; CR43001-RA; Dmel\CR43001-RA
  • mir-276a-RB; Dmel\mir-276a-RB; CR43001-RB; Dmel\CR43001-RB
  • mir-276a-RM; Dmel\mir-276a-RM; CR43001-RM; Dmel\CR43001-RM

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in miRNA-mediated gene silencing by mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in miRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in olfactory learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    10365228..10365325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_048253.1 RNA Sequence

    Status: REVIEWED

Gene LinkOut

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Molecular Biology Databases
Research Materials