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Cnih2 cornichon family AMPA receptor auxiliary protein 2 [ Mus musculus (house mouse) ]

Gene ID: 12794, updated on 28-Oct-2024

Summary

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Official Symbol
Cnih2provided by MGI
Official Full Name
cornichon family AMPA receptor auxiliary protein 2provided by MGI
Primary source
MGI:MGI:1277225
See related
Ensembl:ENSMUSG00000024873 AllianceGenome:MGI:1277225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cnil; CNIH-2
Summary
This gene encodes a protein that is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. This protein is similar to a Drosophila protein involved in anterior-posterior and dorsal-ventral patterning. Cnih2 conditional knockout mice exhibit reduced AMPA receptor synaptic transmission in the hippocampus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Expression
Biased expression in CNS E18 (RPKM 138.4), whole brain E14.5 (RPKM 130.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Cnih2 in Genome Data Viewer
Location:
19 A; 19 4.24 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5142896..5148549, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5092868..5098521, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1968 Neighboring gene uncharacterized LOC132660285 Neighboring gene CD248 antigen, endosialin Neighboring gene STARR-positive B cell enhancer ABC_E7627 Neighboring gene transmembrane protein 151A Neighboring gene Yip1 interacting factor homolog A (S. cerevisiae) Neighboring gene RAB1B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E1969 Neighboring gene kinesin light chain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The regulation of glutamate receptor trafficking and function by TARPs and other transmembrane auxiliary subunits. Straub C, et al. Curr Opin Neurobiol, 2012 Jun. PMID 21993243, Free PMC Article
  2. Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators. Schober DA, et al. J Biol Chem, 2011 Apr 15. PMID 21343286, Free PMC Article
  3. Gating and modulation of a hetero-octameric AMPA glutamate receptor. Zhang D, et al. Nature, 2021 Jun. PMID 34079129, Free PMC Article
  4. Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. Gill MB, et al. J Neurosci, 2011 May 4. PMID 21543622, Free PMC Article
  5. The mouse cornichon gene family. Hwang SY, et al. Dev Genes Evol, 1999 Feb. PMID 10022955

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gating and modulation of a hetero-octameric AMPA glutamate receptor.
    Title: Gating and modulation of a hetero-octameric AMPA glutamate receptor.
  2. Cornichon-2 and cornichon-3 dictate subunit-specific AMPA receptor trafficking and synaptic transmission.
    Title: Cornichon proteins determine the subunit composition of synaptic AMPA receptors.
  3. Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators.
    Title: Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators.
  4. Cornichon homolog 2 (CNIH-2) associates with TARP gamma-8 in hippocampus postsynaptic densities; CNIH-2 protein levels are diminished in transmembrane AMPA receptor regulatory protein (TARP) gamma-8 knockout mice.
    Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC118475

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within localization within membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of anterograde synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of receptor localization to synapse ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of AMPA receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of AMPA receptor activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein cornichon homolog 2
Names
cornichon homolog 2
cornichon-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302333.1 → NP_001289262.1  protein cornichon homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001289262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC124502, AK141483, CX243776
    UniProtKB/TrEMBL
    Q3SYI8
    Conserved Domains (1) summary
    pfam03311
    Location:19 → 106
    Cornichon; Cornichon protein

  2. NM_009920.4 → NP_034050.1  protein cornichon homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_034050.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK141483, CX243776
    Consensus CDS
    CCDS29451.1
    UniProtKB/Swiss-Prot
    O35089
    UniProtKB/TrEMBL
    Q3SYI8
    Related
    ENSMUSP00000025805.7, ENSMUST00000025805.8
    Conserved Domains (1) summary
    pfam03311
    Location:7 → 151
    Cornichon; Cornichon protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5142896..5148549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35089.2 GenPept UniProtKB/Swiss-Prot:O35089

Gene LinkOut

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