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LOC127887783 OCT4-NANOG hESC enhancer GRCh37_chr17:71166424-71167002 [ Homo sapiens (human) ]

Gene ID: 127887783, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127887783
Gene description
OCT4-NANOG hESC enhancer GRCh37_chr17:71166424-71167002
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors. [provided by RefSeq, Dec 2022]
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Genomic context

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Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (73170285..73170863)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (74060077..74060655)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 member 11 Neighboring gene Sharpr-MPRA regulatory region 7306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:71085784-71086284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:71086285-71086785 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:71087756-71087987 Neighboring gene autophagy related 12 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:71128061-71128610 Neighboring gene MPRA-validated peak2987 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8920 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:71188421-71189180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8921 Neighboring gene RNA polymerase III subunit K pseudogene 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:71195948-71197147 Neighboring gene Sharpr-MPRA regulatory region 2581 Neighboring gene somatostatin receptor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12691 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:71227250-71228026 Neighboring gene component of oligomeric golgi complex 1 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene cleavage and polyadenylation specific factor 4 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_137412.1 

    Range
    101..679
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    73170285..73170863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    74060077..74060655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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