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LOC127819705 OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:132847408-132847929 [ Homo sapiens (human) ]

Gene ID: 127819705, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127819705
Gene description
OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:132847408-132847929
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K4me1 histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (131049145..131049666)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (131984184..131984705)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378562 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:132517184-132518383 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:132642120-132643319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:132699511-132700403 Neighboring gene MPRA-validated peak1130 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:132722795-132723295 Neighboring gene Sharpr-MPRA regulatory region 8952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:132796630-132797497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:132797498-132798364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:132800566-132801066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:132801067-132801567 Neighboring gene microRNA 378c Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:132821112-132821721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:132822677-132823607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:132834068-132834857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:132834858-132835646 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:132845839-132846362 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:132846885-132847407 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:132848100-132849299 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:132854747-132855248 Neighboring gene uncharacterized LOC107984186 Neighboring gene TCERG1L antisense RNA 1 Neighboring gene transcription elongation regulator 1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_121174.1 

    Range
    101..622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    131049145..131049666
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    131984184..131984705
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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