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UBXN10 UBX domain protein 10 [ Homo sapiens (human) ]

Gene ID: 127733, updated on 5-Mar-2024

Summary

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Official Symbol
UBXN10provided by HGNC
Official Full Name
UBX domain protein 10provided by HGNC
Primary source
HGNC:HGNC:26354
See related
Ensembl:ENSG00000162543 MIM:616783; AllianceGenome:HGNC:26354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBXD3
Summary
Involved in cilium assembly. Located in cilium. Colocalizes with intraciliary transport particle B. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 9.4), lung (RPKM 3.6) and 16 other tissues See more
Orthologs
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Genomic context

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See UBXN10 in Genome Data Viewer
Location:
1p36.12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (20183331..20196050)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (20006726..20019694)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20512589..20522543)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20468424-20468924 Neighboring gene phospholipase A2 group IIF Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20474795-20475295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:20476004-20476630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20479806-20480357 Neighboring gene uncharacterized LOC117779438 Neighboring gene phospholipase A2 group IIC Neighboring gene ATAC-STARR-seq lymphoblastoid active region 316 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:20511679-20512878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 317 Neighboring gene uncharacterized LOC105376825 Neighboring gene uncharacterized LOC105376826 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:20537509-20538708

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Alexandru G, et al. Cell, 2008 Sep 5. PMID 18775313, Free PMC Article
  2. Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. Raman M, et al. Nat Cell Biol, 2015 Oct. PMID 26389662, Free PMC Article
  3. LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells. Trepte P, et al. Mol Syst Biol, 2018 Jul 11. PMID 29997244, Free PMC Article
  4. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Tomkins JE, et al. Proteomics, 2018 May. PMID 29513927, Free PMC Article
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that UBXN10 localizes to cilia in a AAA-ATPase VCP-dependent manner and both VCP and UBXN10 are required for ciliogenesis.
    Title: Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25429

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle B IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
UBX domain-containing protein 10
Names
UBX domain containing 3
UBX domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152376.5 → NP_689589.1  UBX domain-containing protein 10

    See identical proteins and their annotated locations for NP_689589.1

    Status: VALIDATED

    Source sequence(s)
    BX648631, Z98257
    Consensus CDS
    CCDS205.1
    UniProtKB/Swiss-Prot
    Q5R386, Q96LJ8
    Related
    ENSP00000364240.3, ENST00000375099.4
    Conserved Domains (1) summary
    cl25424
    Location:196 → 269
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    20183331..20196050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540699.4 → XP_011539001.1  UBX domain-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011539001.1

    UniProtKB/Swiss-Prot
    Q5R386, Q96LJ8
    Conserved Domains (1) summary
    cl25424
    Location:196 → 269
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

  2. XM_005245742.5 → XP_005245799.1  UBX domain-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_005245799.1

    UniProtKB/Swiss-Prot
    Q5R386, Q96LJ8
    Conserved Domains (1) summary
    cl25424
    Location:196 → 269
    TGS; The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    20006726..20019694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334395.1 → XP_054190370.1  UBX domain-containing protein 10 isoform X1

    UniProtKB/Swiss-Prot
    Q5R386, Q96LJ8

  2. XM_054334396.1 → XP_054190371.1  UBX domain-containing protein 10 isoform X1

    UniProtKB/Swiss-Prot
    Q5R386, Q96LJ8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LJ8.1 GenPept UniProtKB/Swiss-Prot:Q96LJ8

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