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LOC127460509 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:141901324-141901954 [ Homo sapiens (human) ]

Gene ID: 127460509, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127460509
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:141901324-141901954
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
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Genomic context

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Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (140891225..140891855)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (142011201..142011831)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902099 Neighboring gene protein tyrosine kinase 2 Neighboring gene microRNA 151a Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:141901955-141902583 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:141903275-141903488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141959143-141960131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28038 Neighboring gene RNA, 5S ribosomal pseudogene 278 Neighboring gene Sharpr-MPRA regulatory region 10587 Neighboring gene NANOG hESC enhancer GRCh37_chr8:141986399-141986923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142026737-142027298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142030905-142031616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142032328-142033038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142033039-142033749 Neighboring gene uncharacterized LOC105375783 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:142036197-142037048 and GRCh37_chr8:142037049-142037899

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_115278.1 

    Range
    101..731
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    140891225..140891855
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    142011201..142011831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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