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LOC127459698 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:68632133-68632636 [ Homo sapiens (human) ]

Gene ID: 127459698, updated on 27-Aug-2024

Summary

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Gene symbol
LOC127459698
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:68632133-68632636
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (67719898..67720401)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (68146327..68146830)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A6 Neighboring gene uncharacterized LOC105375886 Neighboring gene MT-ND4L pseudogene 27 Neighboring gene MT-ATP6 pseudogene 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:68552088-68552901 Neighboring gene MT-CO3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 5318 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:68631627-68632132 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:68632637-68633142 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:68633143-68633647 Neighboring gene Sharpr-MPRA regulatory region 913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:68644182-68644682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:68658421-68658921 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:68766696-68767468 Neighboring gene NANOG hESC enhancer GRCh37_chr8:68796257-68797054 Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 6 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:68867393-68868063 Neighboring gene NANOG hESC enhancer GRCh37_chr8:68882966-68883467 Neighboring gene phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 Neighboring gene MPRA-validated peak7060 silencer Neighboring gene uncharacterized LOC105375888

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_114467.1 

    Range
    101..604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    67719898..67720401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    68146327..68146830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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