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LOC127456903 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:83088278-83089221 [ Homo sapiens (human) ]

Gene ID: 127456903, updated on 27-Aug-2024

Summary

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Gene symbol
LOC127456903
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:83088278-83089221
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
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Genomic context

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Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (83458962..83459905)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (84709146..84710093)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene piccolo presynaptic cytomatrix protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:82653064-82653634 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:82653635-82654203 Neighboring gene RNA, 5S ribosomal pseudogene 235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26214 Neighboring gene uncharacterized LOC105375377 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:82833944-82834566 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:82841089-82841665 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:82840511-82841088 Neighboring gene semaphorin 3E Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:83089222-83090164 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:83093938-83094880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26215 Neighboring gene uncharacterized LOC105375378 Neighboring gene NANOG hESC enhancer GRCh37_chr7:83126208-83126709 Neighboring gene RAD23B pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_111678.1 

    Range
    101..1044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    83458962..83459905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    84709146..84710093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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