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LOC127407054 OCT4-NANOG hESC enhancer GRCh37_chr6:111799845-111800569 [ Homo sapiens (human) ]

Gene ID: 127407054, updated on 27-Aug-2024

Summary

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Gene symbol
LOC127407054
Gene description
OCT4-NANOG hESC enhancer GRCh37_chr6:111799845-111800569
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors. [provided by RefSeq, Oct 2022]
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Genomic context

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Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (111478642..111479366)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (112661640..112662364)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene REV3 like, DNA directed polymerase zeta catalytic subunit Neighboring gene FCF1 pseudogene 5 Neighboring gene MPRA-validated peak6034 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr6:111751696-111751904 Neighboring gene MPRA-validated peak6035 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24943 Neighboring gene bromodomain containing 7 pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:111798355-111799247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17479 Neighboring gene TRAF3IP2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24947 Neighboring gene uncharacterized LOC107986520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:111828147-111828670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:111828671-111829193 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_87727 Neighboring gene uncharacterized LOC107986522

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_109025.1 

    Range
    101..825
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    111478642..111479366
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    112661640..112662364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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