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LOC127404301 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149820554-149821093 [ Homo sapiens (human) ]

Gene ID: 127404301, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127404301
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149820554-149821093
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127404301 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (150440991..150441530)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (150977525..150978064)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149820554..149821093)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23412 Neighboring gene CD74 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149792263-149792832 Neighboring gene uncharacterized LOC124901106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:149807381-149807882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:149807883-149808382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23416 Neighboring gene MPRA-validated peak5536 silencer Neighboring gene MPRA-validated peak5537 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149828819-149829757 Neighboring gene ribosomal protein S14 Neighboring gene MPRA-validated peak5538 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149840208-149840834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149843737-149844462 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82371 Neighboring gene NDST1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:149865131-149865786

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_106250.1 

    Range
    101..640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    150440991..150441530
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    150977525..150978064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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