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LOC127402712 H3K27ac hESC enhancer GRCh37_chr5:33440417-33441004 [ Homo sapiens (human) ]

Gene ID: 127402712, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127402712
Gene description
H3K27ac hESC enhancer GRCh37_chr5:33440417-33441004
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (33440311..33440898)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (33554910..33555497)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900637 Neighboring gene NANOG hESC enhancer GRCh37_chr5:33293474-33293975 Neighboring gene NANOG hESC enhancer GRCh37_chr5:33299775-33300300 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:33311980-33313179 Neighboring gene NANOG hESC enhancer GRCh37_chr5:33362859-33363522 Neighboring gene translation machinery-associated protein 7-like Neighboring gene Sharpr-MPRA regulatory region 14601 Neighboring gene TARS1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22455 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:33441593-33442179 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:33447877-33448390 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:33448391-33448904 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:33460526-33461725 Neighboring gene threonyl-tRNA synthetase 1 Neighboring gene NANOG hESC enhancer GRCh37_chr5:33482334-33483024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:33488491-33488992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:33488993-33489492 Neighboring gene TOMM40 pseudogene 3 Neighboring gene uncharacterized LOC105374717

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 22453

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_104661.1 

    Range
    101..688
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    33440311..33440898
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    33554910..33555497
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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