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PRXL2B peroxiredoxin like 2B [ Homo sapiens (human) ]

Gene ID: 127281, updated on 3-Apr-2024

Summary

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Official Symbol
PRXL2Bprovided by HGNC
Official Full Name
peroxiredoxin like 2Bprovided by HGNC
Primary source
HGNC:HGNC:28390
See related
Ensembl:ENSG00000157870 AllianceGenome:HGNC:28390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf93; FAM213B
Summary
Predicted to enable antioxidant activity and prostaglandin-F synthase activity. Predicted to be involved in prostaglandin biosynthetic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 15.1), small intestine (RPKM 14.9) and 24 other tissues See more
Orthologs
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Genomic context

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See PRXL2B in Genome Data Viewer
Location:
1p36.32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (2586523..2591468)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (2028168..2033113)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (2517962..2522907)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TNFRSF14 antisense RNA 1 Neighboring gene uncharacterized LOC100996583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2498904-2499776 Neighboring gene TNF receptor superfamily member 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2508969-2509605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2519024-2519656 Neighboring gene membrane metalloendopeptidase like 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:2556762-2557011 Neighboring gene Sharpr-MPRA regulatory region 11692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2562185-2562685 Neighboring gene MPRA-validated peak16 silencer Neighboring gene MMEL1 antisense RNA 1 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2586483-2586987 Neighboring gene Sharpr-MPRA regulatory region 15700 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2587878-2588769 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2588891-2589402 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2589915-2590426 Neighboring gene tetratricopeptide repeat domain 34 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2597430-2597930 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2597931-2598431 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2600600-2601101 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2601784-2602520 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2603256-2603991 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2607057-2607636 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2607637-2608216 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2609432-2609933 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2610686-2611577 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2613783-2614607 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2628928-2629429 Neighboring gene uncharacterized LOC105378602

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily. Moriuchi H, et al. J Biol Chem, 2008 Jan 11. PMID 18006499
  2. Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. Yoshikawa K, et al. Brain Res, 2011 Jan 7. PMID 20950588
  3. Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. Castellano S, et al. EMBO Rep, 2004 Jan. PMID 14710190, Free PMC Article
  4. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Anderson CA, et al. Nat Genet, 2011 Mar. PMID 21297633, Free PMC Article
  5. BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A. Mao CG, et al. Thorac Cancer, 2020 Nov. PMID 33001583, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26818, DKFZp547M123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables prostaglandin-F synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prostaglandin-F synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in prostaglandin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in myelin sheath ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
prostamide/prostaglandin F synthase
Names
family with sequence similarity 213 member B
prostamide/PG F synthase
prostamide/PGF synthase
thioredoxin-type PGF synthase
NP_001182665.4
NP_001182666.4
NP_001182667.4
NP_001182669.4
NP_001182670.4
NP_689584.5
XP_006710417.1
XP_011538967.1
XP_047301361.1
XP_047301362.1
XP_054184576.1
XP_054184577.1
XP_054184578.1
XP_054184579.1
XP_054190308.1
XP_054190309.1
XP_054190310.1
XP_054190311.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195736.3 → NP_001182665.4  prostamide/prostaglandin F synthase isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).
    Source sequence(s)
    AK057027, AK075273, BM976058, DC351872
    Consensus CDS
    CCDS72690.1
    UniProtKB/TrEMBL
    A0A0A0MT35
    Related
    ENSP00000413218.3, ENST00000444521.6
    Conserved Domains (1) summary
    cd02970
    Location:18 → 185
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  2. NM_001195737.3 → NP_001182666.4  prostamide/prostaglandin F synthase isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses three different splice sites in the coding region, compared to variant 1. The resulting protein (isoform c) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK075273, AK303504, BM976058, DC351872
    UniProtKB/TrEMBL
    J3KRV9
    Related
    ENST00000484099.5
    Conserved Domains (1) summary
    cd02970
    Location:18 → 123
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  3. NM_001195738.3 → NP_001182667.4  prostamide/prostaglandin F synthase isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two different splice sites in the coding region which changes the reading frame, compared to variant 1. The resulting protein (isoform d) is shorter and has a distinct C-terminus when it is compared to isoform a.
    Source sequence(s)
    AK075273, BM976058, DC351872
    Consensus CDS
    CCDS90843.1
    UniProtKB/TrEMBL
    J3KPF6
    Related
    ENSP00000367684.2, ENST00000378427.6
    Conserved Domains (1) summary
    cd02970
    Location:18 → 154
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  4. NM_001195740.3 → NP_001182669.4  prostamide/prostaglandin F synthase isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two different splice sites and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK075273, AK316243, BM976058, DC351872
    Consensus CDS
    CCDS72691.1
    UniProtKB/TrEMBL
    A0A0A0MRV4
    Related
    ENSP00000367682.6, ENST00000378425.9
    Conserved Domains (1) summary
    cd02970
    Location:18 → 123
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  5. NM_001195741.3 → NP_001182670.4  prostamide/prostaglandin F synthase isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses two different splice sites and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform f) is shorter when it is compared to isoform a.
    Source sequence(s)
    AK075273, AK298926, BM976058, DC351872
    Consensus CDS
    CCDS55564.2
    UniProtKB/TrEMBL
    A0A2P0CTH9, A0A2P0CU24
    Related
    ENSP00000443605.2, ENST00000537325.6
    Conserved Domains (1) summary
    cd02970
    Location:18 → 123
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  6. NM_152371.5 → NP_689584.5  prostamide/prostaglandin F synthase isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in an internal coding region exon, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.
    Source sequence(s)
    AF425266, AK075273, BC022547, BM976058, DC351872
    Consensus CDS
    CCDS44.3
    UniProtKB/Swiss-Prot
    A8K793, B3KPY3, B4DQR9, B4E0S5, B7ZAC8, B9DI90, B9DI92, J3KQD0, Q8N2H0, Q8TBF2
    UniProtKB/TrEMBL
    A0A2P0CTB1
    Related
    ENSP00000394405.4, ENST00000419916.8
    Conserved Domains (1) summary
    cd02970
    Location:18 → 167
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RNA

  1. NR_036637.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate 5'-most exon and an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK075273, BM976058, BQ709693, DA495138

  2. NR_036638.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate 5'-most exon and two alternate internal splice sites, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK075273, BI908668, BM976058, DA292832

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    2586523..2591468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445405.1 → XP_047301361.1  prostamide/prostaglandin F synthase isoform X1

  2. XM_011540665.2 → XP_011538967.1  prostamide/prostaglandin F synthase isoform X3

    See identical proteins and their annotated locations for XP_011538967.1

    UniProtKB/TrEMBL
    A0A0A0MT35
    Conserved Domains (1) summary
    cd02970
    Location:48 → 140
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  3. XM_047445406.1 → XP_047301362.1  prostamide/prostaglandin F synthase isoform X4

    UniProtKB/TrEMBL
    J3KPF5
    Related
    ENSP00000367681.5, ENST00000378424.9

  4. XM_006710354.4 → XP_006710417.1  prostamide/prostaglandin F synthase isoform X2

    See identical proteins and their annotated locations for XP_006710417.1

    Conserved Domains (1) summary
    cd02970
    Location:48 → 153
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187515.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    137713..142658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328601.1 → XP_054184576.1  prostamide/prostaglandin F synthase isoform X1

  2. XM_054328603.1 → XP_054184578.1  prostamide/prostaglandin F synthase isoform X3

  3. XM_054328604.1 → XP_054184579.1  prostamide/prostaglandin F synthase isoform X4

    UniProtKB/TrEMBL
    J3KPF5

  4. XM_054328602.1 → XP_054184577.1  prostamide/prostaglandin F synthase isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    2028168..2033113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334333.1 → XP_054190308.1  prostamide/prostaglandin F synthase isoform X1

  2. XM_054334335.1 → XP_054190310.1  prostamide/prostaglandin F synthase isoform X3

  3. XM_054334336.1 → XP_054190311.1  prostamide/prostaglandin F synthase isoform X4

    UniProtKB/TrEMBL
    J3KPF5

  4. XM_054334334.1 → XP_054190309.1  prostamide/prostaglandin F synthase isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TBF2.1 GenPept UniProtKB/Swiss-Prot:Q8TBF2

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