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Ckmt1 creatine kinase, mitochondrial 1, ubiquitous [ Mus musculus (house mouse) ]

Gene ID: 12716, updated on 3-Nov-2024

Summary

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Official Symbol
Ckmt1provided by MGI
Official Full Name
creatine kinase, mitochondrial 1, ubiquitousprovided by MGI
Primary source
MGI:MGI:99441
See related
Ensembl:ENSMUSG00000000308 AllianceGenome:MGI:99441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mt-CK; mi-CK; U-MtCK; mia-CK; ScCKmit; UbCKmit
Summary
Predicted to enable creatine kinase activity and identical protein binding activity. Involved in negative regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system; sensory organ; and urinary system. Orthologous to human CKMT1A (creatine kinase, mitochondrial 1A) and CKMT1B (creatine kinase, mitochondrial 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 828.0), duodenum adult (RPKM 727.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Ckmt1 in Genome Data Viewer
Location:
2 E5; 2 60.37 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121188257..121194218)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121357773..121363737)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tubulin, gamma complex component 4 Neighboring gene transformation related protein 53 binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_05522 Neighboring gene STARR-seq mESC enhancer starr_05523 Neighboring gene STARR-positive B cell enhancer ABC_E2640 Neighboring gene STARR-seq mESC enhancer starr_05524 Neighboring gene STARR-positive B cell enhancer ABC_E5972 Neighboring gene STARR-seq mESC enhancer starr_05525 Neighboring gene microtubule-associated protein 1 A Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E640 Neighboring gene predicted gene, 33947 Neighboring gene stereocilin Neighboring gene cation channel, sperm associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E9202 Neighboring gene STARR-positive B cell enhancer ABC_E3397 Neighboring gene protein disulfide isomerase associated 3 Neighboring gene elongation factor RNA polymerase II-like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse ubiquitous mitochondrial creatine kinase: gene organization and consequences from inactivation in mouse embryonic stem cells. Steeghs K, et al. DNA Cell Biol, 1995 Jun. PMID 7598809
  2. In the absence of phosphate shuttling, exercise reveals the in vivo importance of creatine-independent mitochondrial ADP transport. Miotto PM, et al. Biochem J, 2016 Sep 15. PMID 27402793
  3. Mice lacking the UbCKmit isoform of creatine kinase reveal slower spatial learning acquisition, diminished exploration and habituation, and reduced acoustic startle reflex responses. Streijger F, et al. Mol Cell Biochem, 2004 Jan-Feb. PMID 14977190
  4. Mice deficient in ubiquitous mitochondrial creatine kinase are viable and fertile. Steeghs K, et al. Biochim Biophys Acta, 1995 Jun 30. PMID 7619831
  5. Use of gene targeting for compromising energy homeostasis in neuro-muscular tissues: the role of sarcomeric mitochondrial creatine kinase. Steeghs K, et al. J Neurosci Methods, 1997 Jan. PMID 9125373

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease.
    Title: Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease.
  2. Ckmt1 is Dispensable for Mitochondrial Bioenergetics Within White/Beige Adipose Tissue.
    Title: Ckmt1 is Dispensable for Mitochondrial Bioenergetics Within White/Beige Adipose Tissue.
  3. Mechanistic studies showed lncRNA n335586 promoted hepatocellular carcinoma (HCC) cells migration and invasion through facilitating the expression of its host gene mitochondrial creatine kinase (CKMT1A) by competitively binding miR-924.
    Title: LncRNA n335586/miR-924/CKMT1A axis contributes to cell migration and invasion in hepatocellular carcinoma cells.
  4. Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation
    Title: Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation.
  5. mitochondrial creatine kinase expression in hepatocellular carcinoma may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator
    Title: High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential.
  6. the knock-down of the mitochondrial creatine kinase-1 (CKMT1) by RNA interference causes the dissipation of the mitochondrial membrane potential
    Title: Reconstitution of CKMT1 expression fails to rescue cells from mitochondrial membrane potential dissipation: implications for controlling RNAi experiments.
  7. Mt-CK(-/-) on a C57BL/6 background do not develop LV hypertrophy or dysfunction even up to 1 year, and this may be explained by a compensatory increase in MM-CK activity and mitochondrial volume
    Title: Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.
  8. Data suggest that amyloid precursor protein may regulate cellular energy levels and mitochondrial function via a direct interaction and stabilization of ubiquitous mitochondrial creatine kinase.
    Title: Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins.
  9. UbCKmit was expressed selectively in neurons and localized in their mitochondria in dendrites, cell bodies
    Title: Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis.
  10. Brain type and mitochondrial ubiquitous CK double knockout mice have a reduced body weight, and demonstrate a severely impaired spatial learning in both a dry and a wet maze, lower nestbuilding activity and diminished acoustic startle reflex responses.
    Title: Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables creatine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables creatine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables creatine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphocreatine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphocreatine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner-outer membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath HDA PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
creatine kinase U-type, mitochondrial
Names
acidic-type mitochondrial creatine kinase
ubiquitous mitochondrial creatine kinase
NP_001341998.1
NP_001403881.1
NP_001403882.1
NP_001403883.1
NP_001403884.1
NP_001403885.1
NP_001403886.1
NP_034027.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355069.1 → NP_001341998.1  creatine kinase U-type, mitochondrial isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL845466
    Consensus CDS
    CCDS16640.1
    UniProtKB/Swiss-Prot
    P30275
    UniProtKB/TrEMBL
    Q545N7
    Related
    ENSMUSP00000077349.3, ENSMUST00000078222.9
    Conserved Domains (1) summary
    cd00716
    Location:50 → 407
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

  2. NM_001416952.1 → NP_001403881.1  creatine kinase U-type, mitochondrial isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL845466
    UniProtKB/Swiss-Prot
    P30275
    UniProtKB/TrEMBL
    Q545N7

  3. NM_001416953.1 → NP_001403882.1  creatine kinase U-type, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL845466

  4. NM_001416954.1 → NP_001403883.1  creatine kinase U-type, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL845466

  5. NM_001416955.1 → NP_001403884.1  creatine kinase U-type, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL845466

  6. NM_001416956.1 → NP_001403885.1  creatine kinase U-type, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL845466

  7. NM_001416957.1 → NP_001403886.1  creatine kinase U-type, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL845466

  8. NM_009897.4 → NP_034027.1  creatine kinase U-type, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_034027.1

    Status: VALIDATED

    Source sequence(s)
    AL845466
    Consensus CDS
    CCDS16640.1
    UniProtKB/Swiss-Prot
    P30275
    UniProtKB/TrEMBL
    Q545N7
    Related
    ENSMUSP00000000317.6, ENSMUST00000000317.13
    Conserved Domains (1) summary
    cd00716
    Location:50 → 407
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121188257..121194218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30275.1 GenPept UniProtKB/Swiss-Prot:P30275

Gene LinkOut

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