U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126863182 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:49583849-49585048 [ Homo sapiens (human) ]

Gene ID: 126863182, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126863182
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:49583849-49585048
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC126863182 in Genome Data Viewer
Location:
chromosome: 22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (49187923..49189122)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (49692538..49693694)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr22:49444419-49444575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49472572-49473132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49473133-49473691 Neighboring gene neuronal hypoxia inducible, placenta associated Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:49479476-49480675 Neighboring gene uncharacterized LOC105373086 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:49492353-49492524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49492933-49493434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49493435-49493934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49494904-49495901 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63615 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:49546439-49546996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:49548111-49548668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49576267-49576766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49579645-49580415 Neighboring gene MPRA-validated peak4516 silencer Neighboring gene ribosomal protein L35 pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49637011-49637512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49637513-49638012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49656771-49657286 Neighboring gene NANOG hESC enhancer GRCh37_chr22:49665229-49665768 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:49678386-49679585 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:49686488-49687074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:49687075-49687660 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:49697353-49697914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:49700204-49700897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:49746095-49746659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:49768106-49769047 Neighboring gene uncharacterized LOC124905143

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087678.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    49187923..49189122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    49692538..49693694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases