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LOC126863180 CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:48841523-48842722 [ Homo sapiens (human) ]

Gene ID: 126863180, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126863180
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:48841523-48842722
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (48445711..48446910)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (48938198..48939392)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48736673-48737298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48737299-48737924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48741753-48742340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48742341-48742928 Neighboring gene uncharacterized LOC105373081 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48765615-48766210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48772420-48772926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48772927-48773431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48792732-48793724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48810064-48810602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48810603-48811140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48819797-48820788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48828944-48829484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48831787-48832288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19276 Neighboring gene uncharacterized LOC124905142 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48887443-48887948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48890918-48891778 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48892641-48893500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48895067-48895980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48902339-48903338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48906445-48907385 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48907386-48908325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48911142-48911882 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:48918523-48919026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48923229-48923730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48923731-48924230 Neighboring gene TAFA chemokine like family member 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48929759-48930260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48930261-48930760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:48933150-48933964 Neighboring gene uncharacterized LOC284933

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087676.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    48445711..48446910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    48938198..48939392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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