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LOC126863130 CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:35300277-35301476 [ Homo sapiens (human) ]

Gene ID: 126863130, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126863130
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:35300277-35301476
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (34904286..34905486)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (35363123..35364323)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373014 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:35156231-35157430 Neighboring gene long intergenic non-protein coding RNA 2885 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:35230355-35230911 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:35232607-35233107 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:35236167-35236890 Neighboring gene uncharacterized LOC124905109 Neighboring gene uncharacterized LOC105373015 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:35345833-35346334 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:35346335-35346834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:35419897-35420488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18889 Neighboring gene uncharacterized LOC124905110 Neighboring gene intestine specific homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087626.1 

    Range
    101..1301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    34904286..34905486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    35363123..35364323
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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