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LOC126863128 BRD4-independent group 4 enhancer GRCh37_chr22:35033073-35034272 [ Homo sapiens (human) ]

Gene ID: 126863128, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126863128
Gene description
BRD4-independent group 4 enhancer GRCh37_chr22:35033073-35034272
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126863128 in Genome Data Viewer
Location:
chromosome: 22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (34637081..34638280)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (35095905..35097104)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (35033073..35034272)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:34950472-34951270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:34951271-34952068 Neighboring gene uncharacterized LOC105373013 Neighboring gene ACO2 pseudogene 1 Neighboring gene uncharacterized LOC105373014 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:35156231-35157430 Neighboring gene long intergenic non-protein coding RNA 2885 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:35230355-35230911 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:35232607-35233107 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:35236167-35236890 Neighboring gene uncharacterized LOC124905109

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087624.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    34637081..34638280
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    35095905..35097104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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