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LOC126863113 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:28113736-28114935 [ Homo sapiens (human) ]

Gene ID: 126863113, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126863113
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:28113736-28114935
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (27717748..27718947)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (28178575..28179774)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27937522-27938022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27938023-27938523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27957435-27957934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27969749-27970322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27971900-27972400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27972401-27972901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27987245-27987744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27999453-27999970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27999971-28000486 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28026616-28027234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28029867-28030460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28033379-28033879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28034092-28034896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28034897-28035700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28037955-28038888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28050431-28050930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28063419-28063918 Neighboring gene Sharpr-MPRA regulatory regions 2672 and 6919 Neighboring gene uncharacterized LOC124905098 Neighboring gene cytoplasmic mesoderm regulator Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:28138404-28138904 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:28138905-28139406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28142924-28143424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28145441-28146311 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28153780-28154462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28161389-28161890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28161891-28162390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28175917-28176543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28181385-28181912 Neighboring gene MN1 proto-oncogene, transcriptional regulator Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr22:28186882-28187858 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28194718-28195264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28195265-28195810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28200153-28200717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28200718-28201281 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:28205997-28206518 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:28206519-28207040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28217251-28217750 Neighboring gene uncharacterized LOC107985529

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087609.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    27717748..27718947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    28178575..28179774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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