U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126863112 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:27870511-27871710 [ Homo sapiens (human) ]

Gene ID: 126863112, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126863112
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:27870511-27871710
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. The major subregion had activity in HCT116 colorectal carcinoma cells, where it was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. Two subregions marked by the H3K27ac and H3K4me1 histone modifications were also shown to be active enhancers by ChIP-STARR-seq in naive human embryonic stem cells. [provided by RefSeq, Nov 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (27474413..27475857)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (27935313..27936757)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724900 Neighboring gene NANOG hESC enhancer GRCh37_chr22:27754348-27754896 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:27769315-27769815 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27803625-27804177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27828998-27829600 Neighboring gene uncharacterized LOC105372980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27833795-27834458 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27857322-27858096 Neighboring gene uncharacterized LOC105372981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27937522-27938022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27938023-27938523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27957435-27957934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27969749-27970322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27972401-27972901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27971900-27972400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27987245-27987744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27999453-27999970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27999971-28000486 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28026616-28027234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28029867-28030460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28033379-28033879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28034092-28034896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28034897-28035700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28037955-28038888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28050431-28050930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28063419-28063918 Neighboring gene Sharpr-MPRA regulatory regions 2672 and 6919 Neighboring gene uncharacterized LOC124905098 Neighboring gene cytoplasmic mesoderm regulator

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

General gene information

Go to the top of the page Help

Other Names

  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27870374-27871095
  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27871096-27871818

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087608.2 

    Range
    101..1545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    27474413..27475857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    27935313..27936757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases