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LOC126863108 CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:27179387-27180586 [ Homo sapiens (human) ]

Gene ID: 126863108, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126863108
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:27179387-27180586
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (26783424..26784623)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (27244334..27245533)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27041123-27041688 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27043802-27044604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27045408-27046209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18797 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:27057049-27058028 Neighboring gene iron-sulfur cluster assembly 2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:27061097-27061597 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27063956-27064539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27064540-27065122 Neighboring gene myocardial infarction associated transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27076707-27077531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27077532-27078355 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:27085634-27086255 Neighboring gene MIAT neighbor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18799 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27146977-27147974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27147975-27148973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27148974-27149971 Neighboring gene Sharpr-MPRA regulatory region 13066 Neighboring gene Sharpr-MPRA regulatory region 7329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27196413-27196924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18800 Neighboring gene Sharpr-MPRA regulatory region 5469 Neighboring gene uncharacterized LOC110091768 Neighboring gene ribosomal protein L15 pseudogene 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087604.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    26783424..26784623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    27244334..27245533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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