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LOC126863080 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:60501357-60502556 [ Homo sapiens (human) ]

Gene ID: 126863080, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126863080
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:60501357-60502556
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. Another subregion was also validated as an enhancer by ChIP-STARR-seq in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Jan 2023]
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Genomic context

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See LOC126863080 in Genome Data Viewer
Location:
chromosome: 20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (61926299..61927856)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (63717359..63718916)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene cadherin 4 Neighboring gene uncharacterized LOC105372703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60009149-60009738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60008559-60009148 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:60011920-60013119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60023738-60024298 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60024299-60024857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60073706-60074206 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:60075832-60077031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60088606-60089115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60106507-60107008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60113444-60114423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60131355-60131856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60131857-60132356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60137997-60138897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60164799-60165300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60173673-60174405 Neighboring gene MPRA-validated peak4296 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr20:60193522-60194023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60203424-60204083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60204084-60204742 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:60231445-60231625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60237181-60237694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60237695-60238208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60263433-60263932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60274679-60275179 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:60284281-60284449 Neighboring gene uncharacterized LOC100128310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60321424-60321924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60321925-60322425 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60328223-60329209 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60329210-60330195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60332068-60332568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60332569-60333069 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60340987-60341560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60342316-60342816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60344183-60344683 Neighboring gene Sharpr-MPRA regulatory region 10002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60377656-60378176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60378177-60378697 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60383971-60384684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60410329-60410830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60434505-60435006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60453666-60454166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60454167-60454667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60466559-60467058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60476138-60477031 Neighboring gene Sharpr-MPRA regulatory region 9437 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60507695-60508426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60509158-60509888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60523619-60524118 Neighboring gene MPRA-validated peak4298 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60527344-60527916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60528727-60529226 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:60538354-60539553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60540456-60541084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60541085-60541714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60551058-60551558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60551559-60552059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60564347-60565309 Neighboring gene uncharacterized LOC105372704 Neighboring gene microRNA 1257 Neighboring gene TATA-box binding protein associated factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60502407-60502914

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087576.2 

    Range
    101..1658
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    61926299..61927856
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187623.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    39974..41534
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    63717359..63718916
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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