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LOC126863013 CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:30914131-30915330 [ Homo sapiens (human) ]

Gene ID: 126863013, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126863013
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:30914131-30915330
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (32326328..32327527)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (34051200..34052399)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene protein O-fucosyltransferase 1 Neighboring gene microRNA 1825 Neighboring gene NANOG hESC enhancer GRCh37_chr20:30858165-30858696 Neighboring gene uncharacterized LOC124904885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30865306-30865816 Neighboring gene kinesin family member 3B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17716 Neighboring gene ASXL transcriptional regulator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31033225-31033886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31035799-31036300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31044389-31045304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31045305-31046220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31046221-31047136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31062343-31063114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31064659-31065430 Neighboring gene nucleolar protein 4 like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12790 Neighboring gene uncharacterized LOC124904886

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087510.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    32326328..32327527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    34051200..34052399
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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