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LOC126862876 BRD4-independent group 4 enhancer GRCh37_chr19:18232970-18234169 [ Homo sapiens (human) ]

Gene ID: 126862876, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862876
Gene description
BRD4-independent group 4 enhancer GRCh37_chr19:18232970-18234169
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862876 in Genome Data Viewer
Location:
chromosome: 19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (18122160..18123359)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (18256584..18257783)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr19:18160178-18160339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18162377-18162878 Neighboring gene ribosomal protein S18 pseudogene 13 Neighboring gene Sharpr-MPRA regulatory region 12288 Neighboring gene interleukin 12 receptor subunit beta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10368 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10369 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10370 Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18220925-18221494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18228711-18229582 Neighboring gene uncharacterized LOC124904650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18256091-18256592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18256593-18257093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14300 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18263346-18264238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18267436-18268294 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:18270202-18270406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18271190-18271739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10375 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14302

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087373.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    18122160..18123359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    18256584..18257783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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