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LOC126862839 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:2626979-2628178 [ Homo sapiens (human) ]

Gene ID: 126862839, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862839
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:2626979-2628178
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2626981..2628180)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2603244..2604443)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 7 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2540747-2541566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2541567-2542386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2543207-2544026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2544027-2544846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2544847-2545665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2546759-2547703 Neighboring gene elongin C pseudogene 28 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2556671-2557284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2559714-2560214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2567191-2567718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2567719-2568246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2575316-2575816 Neighboring gene HNF4 motif-containing MPRA enhancer 50 Neighboring gene Sharpr-MPRA regulatory region 4130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2587299-2588242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:2592455-2592956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2603289-2604055 Neighboring gene RNA, 7SL, cytoplasmic 121, pseudogene Neighboring gene H3K4me1 hESC enhancers GRCh37_chr19:2607315-2608169 and GRCh37_chr19:2608170-2609023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9803 Neighboring gene Sharpr-MPRA regulatory region 3019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2643435-2643934 Neighboring gene microRNA 7850 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2650512-2650687 Neighboring gene GNG7 intron CAGE-defined B cell enhancer Neighboring gene MPRA-validated peak3237 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2678080-2678228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13714 Neighboring gene DIRAS family GTPase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087336.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    2626981..2628180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    2603244..2604443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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