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LOC126862825 CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:76406811-76408010 [ Homo sapiens (human) ]

Gene ID: 126862825, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862825
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:76406811-76408010
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862825 in Genome Data Viewer
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (78646811..78648010)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (78880876..78882079)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:76322286-76322827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:76322828-76323368 Neighboring gene NANOG hESC enhancer GRCh37_chr18:76333901-76334402 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:76336458-76337657 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:76391650-76392849 Neighboring gene uncharacterized LOC105372221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76399811-76400311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76419597-76420098 Neighboring gene uncharacterized LOC124904330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76447079-76447994 Neighboring gene VISTA enhancer hs1011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76480426-76481346 Neighboring gene VISTA enhancer hs1056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76528785-76529642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76539929-76540887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76547900-76548400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76548401-76548901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76569491-76569992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76569993-76570492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76573303-76573813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76589119-76589625 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:76610953-76612152 Neighboring gene uncharacterized LOC105372224 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:76669815-76671014 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:76686389-76687588

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087322.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    78646811..78648010
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315958.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    162731..163930
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187665.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    153345..154544
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    78880876..78882079
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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