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LOC126862822 CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:76302140-76303339 [ Homo sapiens (human) ]

Gene ID: 126862822, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862822
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:76302140-76303339
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (78542140..78543339)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (78776531..78777730)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 655, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:75842390-75842890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:75842891-75843391 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:75844334-75845533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:75848151-75848652 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:75898411-75899054 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:75899055-75899698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:75899699-75900342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:75934781-75935281 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:75936086-75937285 Neighboring gene NANOG hESC enhancer GRCh37_chr18:75967979-75968517 Neighboring gene VISTA enhancer hs634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76027952-76028452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76028453-76028953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76056703-76057204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76057205-76057704 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:76254093-76255292 Neighboring gene uncharacterized LOC105372219 Neighboring gene uncharacterized LOC105372220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:76322286-76322827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:76322828-76323368 Neighboring gene NANOG hESC enhancer GRCh37_chr18:76333901-76334402 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:76336458-76337657 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:76391650-76392849 Neighboring gene uncharacterized LOC105372221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:76399811-76400311

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087319.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    78542140..78543339
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315958.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    48674..49873
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187665.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    48674..49873
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    78776531..78777730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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