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LOC126862741 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:46468263-46469462 [ Homo sapiens (human) ]

Gene ID: 126862741, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862741
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:46468263-46469462
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. In HCT116 colorectal carcinoma cells, a subregion was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. Another subregion was also validated as an enhancer by ChIP-STARR-seq in naive human embryonic stem cells, where it is marked by the H3K4me1 histone modification. [provided by RefSeq, Jan 2023]
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Genomic context

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See LOC126862741 in Genome Data Viewer
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (48941451..48943092)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (49136714..49138355)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene cap binding complex dependent translation initiation factor Neighboring gene uncharacterized LOC105372105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46359045-46359708 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46362171-46363071 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46363072-46363971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46364242-46365020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46365021-46365799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46370909-46371409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46384077-46384578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46388739-46389290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13301 Neighboring gene Sharpr-MPRA regulatory region 12870 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:46404101-46404331 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46419523-46420032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46420541-46421048 Neighboring gene Sharpr-MPRA regulatory region 7610 Neighboring gene uncharacterized LOC124904355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46449409-46450340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46452405-46453366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13304 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46459221-46460106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13306 Neighboring gene NANOG hESC enhancer GRCh37_chr18:46474665-46475166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9441 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:46484995-46485788 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46485789-46486582 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46486583-46487376 Neighboring gene uncharacterized LOC105372108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46488965-46489758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9444 Neighboring gene NANOG hESC enhancer GRCh37_chr18:46510218-46510719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46517299-46517928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46520991-46521760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46521761-46522528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:46522886-46523584 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:46526490-46526679 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46527272-46528182 Neighboring gene SMAD family member 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46534574-46535074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46551737-46552638 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:46556151-46556299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46570761-46571726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:46571727-46572691 Neighboring gene DYM antisense RNA 1 Neighboring gene dymeclin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • H3K4me1 hESC enhancer GRCh37_chr18:46467821-46468778

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087238.2 

    Range
    101..1742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    48941451..48943092
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    49136714..49138355
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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