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LOC126862696 BRD4-independent group 4 enhancer GRCh37_chr18:10769534-10770733 [ Homo sapiens (human) ]

Gene ID: 126862696, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862696
Gene description
BRD4-independent group 4 enhancer GRCh37_chr18:10769534-10770733
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862696 in Genome Data Viewer
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (10769536..10770735)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (10931655..10932850)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene piezo type mechanosensitive ion channel component 2 Neighboring gene KIAA0895-like pseudogene Neighboring gene microRNA 6788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13085 Neighboring gene NANOG hESC enhancer GRCh37_chr18:10921815-10922316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13091 Neighboring gene Sharpr-MPRA regulatory region 14785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13093 Neighboring gene uncharacterized LOC124904249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:11148139-11148977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9298 Neighboring gene uncharacterized LOC105371993

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087193.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    10769536..10770735
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    10931655..10932850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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