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LOC126862624 MED14-independent group 3 enhancer GRCh37_chr17:67603079-67604278 [ Homo sapiens (human) ]

Gene ID: 126862624, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862624
Gene description
MED14-independent group 3 enhancer GRCh37_chr17:67603079-67604278
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC126862624 in Genome Data Viewer
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (69606938..69608137)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (70483899..70485098)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371878 Neighboring gene uncharacterized LOC105371879 Neighboring gene Sharpr-MPRA regulatory region 9140 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67425744-67426560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12654 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67443780-67444760 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67444761-67445742 Neighboring gene uncharacterized LOC105371880 Neighboring gene mitogen-activated protein kinase kinase 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12656 Neighboring gene NANOG hESC enhancer GRCh37_chr17:67502478-67502979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:67565237-67565738 Neighboring gene long intergenic non-protein coding RNA 1483 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:67757718-67758917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67797333-67798295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:67798296-67799257 Neighboring gene MPRA-validated peak2972 silencer Neighboring gene MPRA-validated peak2973 silencer Neighboring gene long intergenic non-protein coding RNA 1497 Neighboring gene uncharacterized LOC105371881 Neighboring gene uncharacterized LOC112267896 Neighboring gene uncharacterized LOC124904053

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 12659

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087121.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    69606938..69608137
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    70483899..70485098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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