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LOC126862591 CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:50104733-50105932 [ Homo sapiens (human) ]

Gene ID: 126862591, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862591
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:50104733-50105932
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862591 in Genome Data Viewer
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (52027373..52028572)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (52895120..52896319)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2073 Neighboring gene ribosomal protein L7 pseudogene 48 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:49675964-49676711 Neighboring gene carbonic anhydrase 10 Neighboring gene carbonic anhydrase 10 repeat instability region Neighboring gene MPRA-validated peak2891 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr17:50133703-50133855 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:50197634-50198833 Neighboring gene Sharpr-MPRA regulatory region 175 Neighboring gene uncharacterized LOC105371829 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:50486474-50487018 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:50487019-50487562 Neighboring gene long intergenic non-protein coding RNA 1982 Neighboring gene NANOG hESC enhancer GRCh37_chr17:50528526-50529375

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087088.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    52027373..52028572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    52895120..52896319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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