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LOC126862579 BRD4-independent group 4 enhancer GRCh37_chr17:45213296-45214495 [ Homo sapiens (human) ]

Gene ID: 126862579, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862579
Gene description
BRD4-independent group 4 enhancer GRCh37_chr17:45213296-45214495
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (47135930..47137129)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47998265..47999464)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene uncharacterized LOC101927060 Neighboring gene leucine rich repeat containing 37 member A17, pseudogene Neighboring gene MPRA-validated peak2870 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45145515-45146016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45146017-45146516 Neighboring gene uncharacterized LOC124904015 Neighboring gene RNA, 7SL, cytoplasmic 270, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45175453-45176078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8621 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:45197166-45197776 Neighboring gene protein GVQW1-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:45266269-45266865 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3215 Neighboring gene cell division cycle 27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12304 Neighboring gene Sharpr-MPRA regulatory region 4457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:45298755-45299410 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:45298098-45298754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8623 Neighboring gene ribosomal protein S2 pseudogene 47 Neighboring gene myosin light chain 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087076.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    47135930..47137129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    47998265..47999464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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