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LOC126862544 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:35278241-35279440 [ Homo sapiens (human) ]

Gene ID: 126862544, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862544
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:35278241-35279440
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (36920960..36922156)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (37908016..37909212)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34983260-34983760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34998295-34999169 Neighboring gene mitochondrial rRNA methyltransferase 1 Neighboring gene MPRA-validated peak2825 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35010359-35010858 Neighboring gene VISTA enhancer hs362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35013913-35014450 Neighboring gene uncharacterized LOC105371750 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:35018784-35018989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35021739-35022238 Neighboring gene uncharacterized LOC105371751 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:35109266-35109439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35148027-35148528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35169882-35170594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35170595-35171307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35173923-35174428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35174429-35174934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35183956-35184456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35184457-35184957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35194089-35194756 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:35207061-35208260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35215835-35216366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35219226-35220198 Neighboring gene Sharpr-MPRA regulatory region 13221 Neighboring gene Sharpr-MPRA regulatory region 9746 Neighboring gene LHX1 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35275423-35275942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35275943-35276460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35289047-35289564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35289565-35290082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35290165-35291080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35292909-35293822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35294081-35294922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35295765-35296606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35298089-35298612 Neighboring gene VISTA enhancer hs363 Neighboring gene LIM homeobox 1 Neighboring gene apoptosis antagonizing transcription factor Neighboring gene microRNA 2909

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_087041.1 

    Range
    101..1297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    36920960..36922156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1157306..1158505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    37908016..37909212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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