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LOC126862435 CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:87173746-87174945 [ Homo sapiens (human) ]

Gene ID: 126862435, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862435
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:87173746-87174945
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862435 in Genome Data Viewer
Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (87140140..87141339)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (93210327..93211526)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2181 Neighboring gene NANOG hESC enhancer GRCh37_chr16:87122126-87122775 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:87127447-87128373 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87132609-87133324 Neighboring gene uncharacterized LOC105371394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87165805-87166621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87183708-87184208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87184209-87184709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87193649-87194198 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:87195966-87197165 Neighboring gene MPRA-validated peak2654 silencer Neighboring gene Sharpr-MPRA regulatory region 1579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87207420-87207920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87207921-87208421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87220006-87220856 Neighboring gene uncharacterized LOC101928708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87269509-87270209 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87270210-87270909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87275853-87276354 Neighboring gene ribosomal protein L39 pseudogene 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086933.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    87140140..87141339
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    93210327..93211526
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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