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LOC126862370 MED14-independent group 3 enhancer GRCh37_chr16:65408883-65410082 [ Homo sapiens (human) ]

Gene ID: 126862370, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862370
Gene description
MED14-independent group 3 enhancer GRCh37_chr16:65408883-65410082
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (65374980..65376179)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (71169171..71170366)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cadherin 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:65105573-65106491 Neighboring gene long intergenic non-protein coding RNA 2126 Neighboring gene NANOG hESC enhancer GRCh37_chr16:65260913-65261414 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65263556-65264056 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65264057-65264557 Neighboring gene uncharacterized LOC124903780 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65268706-65269234 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65269235-65269763 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65269764-65270292 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:65340354-65341222 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:65352533-65353244 Neighboring gene long intergenic non-protein coding RNA 922 Neighboring gene fragile site, distamycin A type, rare, fra(16)(q22.1) Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:65690017-65690516 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:65691608-65692807 Neighboring gene NANOG hESC enhancer GRCh37_chr16:65747170-65747777 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:65761912-65762486 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:65794855-65795592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:65800891-65801391 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:65802715-65803215 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:65805808-65806404 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:65806405-65806999 Neighboring gene uncharacterized LOC107984823 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:65850922-65851531 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:65966974-65968173 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:66008681-66009880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66064029-66064528 Neighboring gene uncharacterized LOC105371316

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086868.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    65374980..65376179
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    71169171..71170366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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