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LOC126862362 BRD4-independent group 4 enhancer GRCh37_chr16:57095254-57096453 [ Homo sapiens (human) ]

Gene ID: 126862362, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862362
Gene description
BRD4-independent group 4 enhancer GRCh37_chr16:57095254-57096453
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57061342..57062541)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62857669..62858868)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57023277-57023776 Neighboring gene Sharpr-MPRA regulatory region 12884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10869 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57033747-57034248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10870 Neighboring gene NLR family CARD domain containing 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10874 Neighboring gene CFAP69 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57060363-57060881 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_43539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57103335-57104060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57104061-57104785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57137039-57137994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57139274-57139873 Neighboring gene copine 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7523 Neighboring gene Sharpr-MPRA regulatory region 3054 Neighboring gene Sharpr-MPRA regulatory region 6435 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57183845-57184634 Neighboring gene proteasome activator subunit 3 interacting protein 1 Neighboring gene NANOG hESC enhancer GRCh37_chr16:57212532-57213113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10884

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086860.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    57061342..57062541
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    62857669..62858868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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