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LOC126862303 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:17665142-17666341 [ Homo sapiens (human) ]

Gene ID: 126862303, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862303
Gene description
P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:17665142-17666341
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862303 in Genome Data Viewer
Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (17571285..17572484)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (17578358..17579557)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene xylosyltransferase 1 Neighboring gene uncharacterized LOC107987234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:17564811-17565312 Neighboring gene uncharacterized LOC105371106 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:17591055-17591654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10513 Neighboring gene NANOG hESC enhancer GRCh37_chr16:17672718-17673219 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:17700860-17702059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:17839175-17839850 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:17840527-17841202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:17838498-17839174 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:17851169-17851784 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:17851785-17852400 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:17870498-17870998 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:17930405-17931604 Neighboring gene uncharacterized LOC107984893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10517 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:18065894-18066422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:18066423-18066951 Neighboring gene ribosomal protein L7 pseudogene 47 Neighboring gene uncharacterized LOC105371108

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086801.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    17571285..17572484
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    17578358..17579557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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