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LOC126862290 BRD4-independent group 4 enhancer GRCh37_chr16:12435179-12436378 [ Homo sapiens (human) ]

Gene ID: 126862290, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862290
Gene description
BRD4-independent group 4 enhancer GRCh37_chr16:12435179-12436378
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (12341322..12342521)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (12378304..12379503)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene sorting nexin 29 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7217 Neighboring gene Sharpr-MPRA regulatory region 9869 Neighboring gene uncharacterized LOC642696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12215085-12215584 Neighboring gene Sharpr-MPRA regulatory region 3169 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:12241842-12242399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12257095-12257595 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:12355210-12355716 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10466 Neighboring gene small nucleolar RNA ACA64 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:12404869-12405376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:12405377-12405883 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:12407183-12407683 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:12408231-12408918 Neighboring gene Sharpr-MPRA regulatory region 2664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12410661-12411592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12426104-12426604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10468 Neighboring gene uncharacterized LOC101927227 Neighboring gene uncharacterized LOC105371087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12479845-12480345 Neighboring gene Sharpr-MPRA regulatory region 12750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10470 Neighboring gene Sharpr-MPRA regulatory region 5052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12529425-12530112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12530113-12530799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:12532613-12533114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12561965-12562466 Neighboring gene uncharacterized LOC124903644

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086788.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    12341322..12342521
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    12378304..12379503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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