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LOC126862278 CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:7629446-7630645 [ Homo sapiens (human) ]

Gene ID: 126862278, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126862278
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:7629446-7630645
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862278 in Genome Data Viewer
Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (7579444..7580643)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (7610929..7612128)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (7629446..7630645)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA binding fox-1 homolog 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:7231546-7232745 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:7234679-7235878 Neighboring gene Sharpr-MPRA regulatory region 8564 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44361 Neighboring gene MPRA-validated peak2487 silencer Neighboring gene ribosomal protein S26 pseudogene 51 Neighboring gene uncharacterized LOC124903640 Neighboring gene NANOG hESC enhancer GRCh37_chr16:7481632-7482288 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:7701751-7702302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:7703336-7703942 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:7758954-7760153 Neighboring gene uncharacterized LOC124900381 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:7814521-7815243 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:7815244-7815965 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:7819497-7820696 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:7917473-7918672 Neighboring gene uncharacterized LOC105371069

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086776.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    7579444..7580643
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    7610929..7612128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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