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LOC126862256 MED14-independent group 3 enhancer GRCh37_chr15:102009487-102010686 [ Homo sapiens (human) ]

Gene ID: 126862256, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862256
Gene description
MED14-independent group 3 enhancer GRCh37_chr15:102009487-102010686
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (101469282..101470481)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (99224543..99225742)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507472 Neighboring gene proprotein convertase subtilisin/kexin type 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101866838-101867338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6890 Neighboring gene PCSK6 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101897421-101898364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101899309-101900252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101900253-101901196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101903043-101903860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101910467-101910968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101910969-101911468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:101926563-101927064 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:101927065-101927564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101951801-101952617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101966524-101967114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101991219-101991952 Neighboring gene Sharpr-MPRA regulatory region 2389 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:101996796-101996999 Neighboring gene uncharacterized LOC124903566 Neighboring gene uncharacterized LOC107987228 Neighboring gene uncharacterized LOC124903567

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086754.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    101469282..101470481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    99224543..99225742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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