U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126862248 MED14-independent group 3 enhancer GRCh37_chr15:100556815-100558014 [ Homo sapiens (human) ]

Gene ID: 126862248, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC126862248
Gene description
MED14-independent group 3 enhancer GRCh37_chr15:100556815-100558014
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes enhancers that were validated by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors in HCT116 colorectal carcinoma cells, but it has limited or no dependence on the MED14 core Mediator complex subunit. Two subregions marked by the H3K27ac and H3K4me1 histone modifications were also shown to be active enhancers by ChIP-STARR-seq in primed human embryonic stem cells. [provided by RefSeq, Nov 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (100016610..100017809)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (97772958..97774157)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 Q2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 11003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100456801-100457665 Neighboring gene Sharpr-MPRA regulatory region 10020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:100515897-100516492 Neighboring gene uncharacterized LOC105371022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:100516493-100517088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:100521898-100522876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:100523855-100524832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100532449-100532963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100532964-100533477 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:100537785-100538412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100538413-100539040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100539041-100539668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100542118-100542966 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 17 Neighboring gene Sharpr-MPRA regulatory region 8829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100624491-100624991 Neighboring gene RNA, 5S ribosomal pseudogene 402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100648765-100649612 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:100651166-100652365 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:100663469-100664668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100739855-100740621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100740622-100741387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100742159-100742696 Neighboring gene Sharpr-MPRA regulatory region 9518 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:100781303-100782502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100805303-100805804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:100819145-100819835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:100849823-100850322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:100880514-100881032 Neighboring gene uncharacterized LOC105371021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10167 Neighboring gene spermatogenesis associated 41

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

General gene information

Go to the top of the page Help

Other Names

  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:100556846-100557368
  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:100557369-100557889

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086746.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    100016610..100017809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    97772958..97774157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases