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LOC126862221 MED14-independent group 3 enhancer GRCh37_chr15:90957593-90958792 [ Homo sapiens (human) ]

Gene ID: 126862221, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862221
Gene description
MED14-independent group 3 enhancer GRCh37_chr15:90957593-90958792
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862221 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90414361..90415560)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (88170376..88171575)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12979 Neighboring gene zinc finger protein 774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90938261-90938762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90938763-90939262 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6820 Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:90955563-90956294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10077 Neighboring gene MPRA-validated peak2420 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr15:90999383-90999894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10078 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:91054233-91054732 Neighboring gene MPRA-validated peak2421 silencer Neighboring gene MPRA-validated peak2422 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10079 Neighboring gene CREB regulated transcription coactivator 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91106113-91106613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6824 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:91126557-91127068 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:91127069-91127580 Neighboring gene uncharacterized LOC124903555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91137296-91137796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10080 Neighboring gene Sharpr-MPRA regulatory region 4613 Neighboring gene uncharacterized LOC124903554

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086719.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    90414361..90415560
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    88170376..88171575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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