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LOC126862190 BRD4-independent group 4 enhancer GRCh37_chr15:80262962-80264161 [ Homo sapiens (human) ]

Gene ID: 126862190, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862190
Gene description
BRD4-independent group 4 enhancer GRCh37_chr15:80262962-80264161
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (79970620..79971819)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (77833521..77834720)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ST20-MTHFS readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9936 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:80216673-80217333 Neighboring gene suppressor of tumorigenicity 20 Neighboring gene ST20 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9937 Neighboring gene farnesyl diphosphate synthase pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9940 Neighboring gene ribonucleotide reductase regulatory subunit M2 pseudogene Neighboring gene BCL2 related protein A1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:80293949-80294721 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:80295257-80296456 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9942 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:80320394-80320775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:80324347-80325092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:80325093-80325836 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:80325837-80326580 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:80332051-80332550 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:80351696-80352024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9943 Neighboring gene zinc finger AN1-type containing 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:80404705-80405431

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086688.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    79970620..79971819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    77833521..77834720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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