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LOC126862156 MED14-independent group 3 enhancer GRCh37_chr15:64736443-64737642 [ Homo sapiens (human) ]

Gene ID: 126862156, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862156
Gene description
MED14-independent group 3 enhancer GRCh37_chr15:64736443-64737642
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (64444244..64445443)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (62253665..62254866)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene casein kinase 1 gamma 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6533 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64652953-64653179 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64673301-64673811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64679750-64680250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64680251-64680751 Neighboring gene PCNA clamp associated factor Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722213-64722724 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722725-64723236 Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene uncharacterized LOC105370861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6535 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9569 Neighboring gene zinc finger protein 609 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64803884-64804071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64820886-64821752 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64831500-64832000 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64832001-64832501 Neighboring gene uncharacterized LOC101930091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9571 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 61 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64849587-64850088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64850089-64850588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64855291-64855860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64855861-64856430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9573 Neighboring gene ribosomal protein S26 pseudogene 50

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086654.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    64444244..64445443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    62253665..62254866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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