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LOC126862146 CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:60699237-60700436 [ Homo sapiens (human) ]

Gene ID: 126862146, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862146
Gene description
CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:60699237-60700436
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862146 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (60407038..60408237)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (58210218..58211417)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:60683199-60683790 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:60684938-60686137 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:60688531-60689122 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:60689123-60689714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6494 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6496 Neighboring gene ribosomal protein L36a pseudogene 44 Neighboring gene annexin A2 Neighboring gene ribosomal protein S10 pseudogene 22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9508 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:60770615-60771142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9509 Neighboring gene interactor of little elongation complex ELL subunit 2 Neighboring gene RORA antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6497 Neighboring gene NANOG hESC enhancer GRCh37_chr15:60848032-60848533 Neighboring gene RAR related orphan receptor A Neighboring gene CYCS pseudogene 38

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086644.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    60407038..60408237
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    58210218..58211417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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