U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC126862084 BRD4-independent group 4 enhancer GRCh37_chr15:27958849-27960048 [ Homo sapiens (human) ]

Gene ID: 126862084, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
LOC126862084
Gene description
BRD4-independent group 4 enhancer GRCh37_chr15:27958849-27960048
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC126862084 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (27713703..27714902)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (25456127..25457326)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (27958849..27960048)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit gamma3 Neighboring gene RNA, 5S ribosomal pseudogene 391 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:27585914-27587113 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:27603646-27604146 Neighboring gene serpin family E member 4, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:27657550-27658104 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:27699000-27700199 Neighboring gene Sharpr-MPRA regulatory region 4259 Neighboring gene NANOG hESC enhancer GRCh37_chr15:27757723-27758304 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:27833083-27833211 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:27883709-27884453 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:27890620-27891400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:27931705-27932684 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:27939287-27940486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:27947009-27947605 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:27996457-27996958 Neighboring gene OCA2 melanosomal transmembrane protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28115926-28116426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28142467-28142967 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:28149284-28149784 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39258 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28228378-28228878 Neighboring gene ribosomal protein L5 pseudogene 32 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28264414-28265082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28268807-28269306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28343756-28344408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:28352349-28352910 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:28352911-28353471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:28359141-28359640 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 15:28365618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:28377589-28378366 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 2 Neighboring gene MPRA-validated peak2277 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:28526505-28527006 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:28537256-28537799 Neighboring gene ribosomal protein L41 pseudogene 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086582.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    27713703..27714902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    25456127..25457326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases