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LOC126862070 BRD4-independent group 4 enhancer GRCh37_chr14:105536095-105537294 [ Homo sapiens (human) ]

Gene ID: 126862070, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126862070
Gene description
BRD4-independent group 4 enhancer GRCh37_chr14:105536095-105537294
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in HCT116 colorectal carcinoma cells, where it was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC126862070 in Genome Data Viewer
Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105069758..105070957)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99314314..99315513)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105536095..105537294)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105485485-105486145 Neighboring gene H3K27ac hESC enhancers GRCh37_chr14:105486597-105487112 and GRCh37_chr14:105487627-105488140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9127 Neighboring gene cell division cycle associated 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9128 Neighboring gene Sharpr-MPRA regulatory region 5751 Neighboring gene uncharacterized LOC124903398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105499947-105500448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105521947-105522722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9132 Neighboring gene G protein-coupled receptor 132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105532273-105532790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105544057-105544557 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:105544918-105545868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105560015-105560637 Neighboring gene long intergenic non-protein coding RNA 2298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105585919-105586418 Neighboring gene jagged canonical Notch ligand 2 Neighboring gene microRNA 6765

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 9139

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086568.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    105069758..105070957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    99314314..99315513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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