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LOC126862018 MED14-independent group 3 enhancer GRCh37_chr14:89894848-89896047 [ Homo sapiens (human) ]

Gene ID: 126862018, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126862018
Gene description
MED14-independent group 3 enhancer GRCh37_chr14:89894848-89896047
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862018 in Genome Data Viewer
Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (89428504..89429703)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (83652225..83653423)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene forkhead box N3 Neighboring gene uncharacterized LOC101928817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:89818959-89819674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8859 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89858093-89858593 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:89865667-89866237 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89869264-89869764 Neighboring gene Sharpr-MPRA regulatory region 4092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:89882738-89883271 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:89883272-89883804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:89891172-89891786 Neighboring gene uncharacterized LOC107984635 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:89898457-89899010 Neighboring gene FOXN3 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:89906553-89907136 Neighboring gene Sharpr-MPRA regulatory region 349 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:89907723-89908306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89919266-89920166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89929363-89929862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89932229-89933148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89933149-89934068 Neighboring gene FOXN3 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8868 Neighboring gene H3K27ac hESC enhancers GRCh37_chr14:90084905-90085406 and GRCh37_chr14:90085407-90085906 Neighboring gene uncharacterized LOC105370617 Neighboring gene RN7SK pseudogene 107

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086516.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    89428504..89429703
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    83652225..83653423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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